HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Lutidine → N-(6-amino-5-iodopyridine-2-yl)-1-isopropyl-1H-pyrazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | 3-Iodopyridine-2,6-diamine | HCID 476218 | — |
| Reactant | 1-(propan-2-yl)-1H-pyrazole-5-carboxylic acid | HCID 3150947 | — |
| Product | N-(6-amino-5-iodopyridine-2-yl)-1-isopropyl-1H-pyrazole-5-carboxamide | HCID 66637081 | 38% |
Reaction Steps
Method A using 3-Iodo-pyridine-2,6-diamine (Preparation 44), 1.6 equivalents of lutidine and 1.5 equivalents of acid chloride prepared from 2-isopropyl-2H-pyrazole-3-carboxylic acid. Purified by trituration with methanol:ethylacetate 1:2 to afford the title compound as a colourless oil (608 mg, 38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134007B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-996c29b2e0a44cb49fb77217aae9ecf3 |
| Source note | uspto-grants-2012_03 |