Methyl iodide → HCID 178418706, compound

HRID 10949Notes

Reaction equation

HRID 10949 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([S:17]([NH:20][CH:21]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])(=[O:19])=[O:18])[CH:12]=2)[CH:8]=[CH:9][CH:10]=1)=[S:3].I[CH3:35]>CO>[NH:1]=[C:2]([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([S:17]([NH:20][CH:21]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])(=[O:18])=[O:19])[CH:12]=2)[CH:8]=[CH:9][CH:10]=1)[S:3][CH3:35]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 21982442Ethyl 3-[({3'-[(aminocarbothioyl)amino][1,1'-biphenyl]-3-yl}sulfonyl)-amino]-3-phenylpropanoate

Product 1

HCID 178418706HCID 178418706, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.42 g of Ethyl 3-[({3′-[(aminocarbothioyl)amino][1,1′-biphenyl]-3-yl}sulfonyl)-amino]-3-phenylpropanoate 14.1.1 were dissolved in 80 ml methanol and 0.89 g Iodomethan were added. After reflux for 2 h, the reaction mixture was concentrated and crystalized from ether to obtain 3.1 g.

Workup

  1. temperatureAfter reflux for 2 h
  2. concentrationthe reaction mixture was concentrated
  3. customcrystalized from ether
  4. customto obtain 3.1 g

Sources & evidence

ORD record
ord-ed743768047447f58cadda2ee9a69749
Source dataset
uspto-grants-2006_08
Patent number
US07094911B2

Reaction notes

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