Hydrazine hydrate (1:1) → 2-(3,4-Dichlorophenyl)-4-(1-hydrazinylideneethyl)thiophene-3-ol

Participants

Reaction Steps

2-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene (50 mg, 0.17 mmol) (prepared by the method disclosed in WO2004/108683) in isopropanol was stirred with hydrazine monohydrate (95 μL/0.19 mmol) at 90° C. for 1 hour, then allowed to cool to room temperature and stirred at 0° C. The precipitated solid was collected by filtration and dried to give 36 mg of the desired product (yield 69%).

Provenance & Evidence