2-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene → HCID 73300007, compound

Participants

Reaction Steps

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (22 mg, 0.075 mmol) in dimethyl sulfoxide (2.0 mL) was heated with 5-(hydrazinocarbonyl)thiophene-2-carboxylic acid [2-(pyrrolidin-1-yl)ethyl]-amide (21 mg, 0.075 mmol) prepared in Reference Synthetic Example 1 at 100° C. for 24 hours. Evaporation of the solvent followed by recrystallization from chloroform (1 mL)-diethyl ether (2 mL) affored 12 mg of the desired product (yield 29%).

Provenance & Evidence