Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

To a solution of racemic(2′R, 3R, 4′S)-2′-[2-(1-tert-butoxycarbonylmethyl-4-piperidinyloxy)-5-iodo-phenyl]-6-chloro-4′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (0.22 g, 0.28 mmol) in dichloromethane (2 mL) was added trifluoroacetic acid (2 mL). The reaction mixture was stirred at room temperature for 18 h, then concentrated. The residue was triturated with dichlormethane and hexanes to give racemic(2′R, 3R, 4′S)-6-chloro-4′-(3-chlorophenyl)-2′-[2-(1-hydroxycarbonylmethyl-4-piperidinyloxy)-5-iodo-phenyl]spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione as trifluoroacetic acid salt: yellow solid (Yield 0.18 g)

Provenance & Evidence