1-Pyrrolidineethanamine → HCID 74931454, compound

Participants

Reaction Steps

In a manner similar to the method described in example 55b, racemic(2′R, 3R, 4′S)-2′-[5-bromo-2-(4-fluorocarbonyl-phenoxy)-phenyl]-6-chloro-4′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (0.18 g, 0.28 mmol) was reacted with N-(2-aminoethyl)pyrrolidine (0.4 g, 3.5 mmol), N-methylmorpholine and 4-dimethylaminopyridine in tetrahydrofuran to give racemic(2′R, 3R, 4′S)-2′-{5-bromo-2-[4-(2-pyrrolidin-1-yl-ethylcarbamoyl)-phenoxy]-phenyl}-6-chloro-4′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione as a white solid (Yield 0.17 g, 83%).

Provenance & Evidence