Potassium Carbonate → 2-[4-(2-Hydroxy-ethoxy)-phenoxy]-5-iodo-benzaldehyde

Participants

Reaction Steps

In a manner similar to the method described in Example 50a, 2-fluoro-5-iodobenzaldehyde (2.5 g, 10 mmol) (Aldrich) was reacted with 4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenol (2.7 g, 10 mmol) and K2CO3 in N,N-dimethylacetamide at 170° C. for 0.5 h to give 2-[4-(2-hydroxy-ethoxy)-phenoxy]-5-iodo-benzaldehyde as a yellow solid (Yield 3.8 g, 98%).

Provenance & Evidence