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Potassium Carbonate → 5-Chloro-2-[4-(2-hydroxy-ethoxy)-phenoxy]-benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Chloro-2-fluorobenzaldehyde | HCID 2773586 | — |
| 反応物 | 4-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenol | HCID 22033378 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 5-Chloro-2-[4-(2-hydroxy-ethoxy)-phenoxy]-benzaldehyde | HCID 57743421 | 75.5% |
反応手順
In a manner similar to the method described in Example 50a, 5-chloro-2-fluorobenzaldehyde (1.2 g, 7.6 mmol) (Aldrich) was reacted with 4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenol (2.1 g, 7.8 mmol) prepared in Example 60b and K2CO3 in N,N-dimethylacetamide at 170° C. for 0.5 h to give 5-chloro-2-[4-(2-hydroxy-ethoxy)-phenoxy]-benzaldehyde as a colorless oil (Yield 1.68 g, 75%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08134001B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-f5dbe5546a7e4a5e88e86dd6d3e801ad |
| 出典メモ | uspto-grants-2012_03 |