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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1095129Generated: October 30, 2026

Potassium Carbonate → HCID 57743385, compound

https://huagongshe.com/reaction/1095129

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant4-(Trifluoromethyl)phenolHCID 67874—
Reactant5-Chloro-2-fluorobenzaldehydeHCID 2773586—
SolventDimethylacetamideHCID 31374—
ProductHCID 57743385HCID 5774338558.2%

Reaction Steps

In a manner similar to the method described in Example 50a, 5-chloro-2-fluorobenzaldehyde (0.88 g, 5.6 mmol) (Beta Pharma) was reacted with 4-trifluoromethylphenol (1 g, 6.6 mmol)(Aldrich) and K2CO3 in N,N-dimethylacetamide to give 5-chloro-2-(4-trifluoromethyl-phenoxy)-benzaldehyde as a yellow solid (Yield 0.98 g, 58%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08134001B2
Source datasetuspto-grants-2012_03
ORD IDord-699a623fb2df4e7d906f41f61dbe6e22
Source noteuspto-grants-2012_03