HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Chloro-2-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chloro-salicylaldehyde | HCID 12481 | — |
| Reactant | 1,4-Dioxaspiro(4.5)decan-8-yl methanesulfonate | HCID 14966741 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Chloro-2-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-benzaldehyde | HCID 57743296 | 34.2% |
Reaction Steps
In a manner similar to the method described in example 4a, 5-chlorosalicylaldehyde (2.32 g, 14.8 mmol) (Aldrich) reacted with methanesulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester (3.5 g, 14.8 mmol) and K2CO3 in N,N-dimethylformamide to give 5-chloro-2-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-benzaldehyde as a colorless oil (Yield 1.5 g, 34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-584440eaf1a4429f9d1a0802a5d18384 |
| Source note | uspto-grants-2012_03 |