HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 178498034, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | Benzoic acid, 5-chloro-2-hydroxy-, methyl ester | HCID 77684 | — |
| Reactant | HCID 178455370 | HCID 178455370 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178498034 | HCID 178498034 | 71.2% |
Reaction Steps
In a manner similar to the method described in example 94b, cis-4-(tert-buyl-dimethyl-silanyloxy)-cyclohexanol (2.7 g, 12 mmol) was reacted with methyl 5-chloro-2-hydroxybenzoate (1.77 g, 9.5 mmol) and diisopropyl azodicarboxylate, triphenylphosphine in tetrahydrofuran to give trans-2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyloxy]-5-chloro-benzoic acid methyl ester as a yellow oil (Yield 2.7 g, 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-e02449977ded4203866e40250ed337ce |
| Source note | uspto-grants-2012_03 |