Aluminium lithium hydride → HCID 178455369, compound

Participants

Reaction Steps

In a manner similar to the method described in example 94c, trans-2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyloxy]-5-chloro-benzoic acid methyl ester (2.7 g, 6.76 mmol) was reacted with LiAlH4 (1 M, 6.76 mL, 6.76 mmol) in ethyl ether, then oxidized with activated MnO2 (4.64 g, 54 mmol) in dichloromethane to give trans-2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyloxy]-5-chloro-benzaldehyde as a white solid (Yield 1.12 g, 44%).

Provenance & Evidence