Dimethylamine, hydrochloride → HCID 86631797, compound

Participants

Reaction Steps

To a mixture of racemic(2′R, 3R, 4′S)-2′-[5-bromo-2-(1-hydroxycarbonyl-1-methyl-ethoxy)-phenyl]-6-chloro-4′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (40 mg, 0.065 mmol), EDCI (18.7 mg, 0.098 mmol), HOBt (15 mg, 0.098 mmol) and DIPEA (75 mg, 0.6 mmol) in THF (2 mL) was added dimethylamine hydrochloride (20 mg, 0.25 mmol). The mixture was stirred at room temperature overnight, purified by prep-HPLC to give the title compound as a white solid (26 mg).

Provenance & Evidence