Sodium Hydroxide → HCID 76567942, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of racemic(2′R, 3R, 4′S)-2′-[5-bromo-2-(2-methoxycarbonyl-2-methyl-propoxy)-phenyl]-6-chloro-4′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (106 mg, 0.16 mmol) in methanol (6 mL) was added a solution of NaOH (30 mg, 0.75 mmol) in water (3 mL). The mixture was heated at 60° C. for 5 h, evaporated to remove methanol, cooled to room temperature, and acidified to “pH” 2 with HCl aq. The precipitate was collected and dried to give the title compound as a white solid (70 mg). m/z (M+H)+: 617

Provenance & Evidence