HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 1-[5-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Chlorotriethylsilane | HCID 13819 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | HCID 57743258 | HCID 57743258 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-[5-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene | HCID 66641285 | — |
Reaction Steps
In a manner similar to the method described in Example 112b, 5-fluoro-2-(tetrahydro-pyran-4-yloxy)-benzaldehyde was treated with LHMDS, acetyl chloride, triethylamine and chloro-triethyl-silane to give the desired compound, which was directly used for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-39706d6b911a4fd499835bbb839d08ad |
| Source note | uspto-grants-2012_03 |