HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Fluorosalicylaldehyde | HCID 2737328 | — |
| Reactant | 4-(Methanesulfonyl)oxytetrahydrothiopyran | HCID 12420265 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)benzaldehyde | HCID 57743182 | — |
Reaction Steps
In a manner similar to the method described in Example 128a, 5-fluoro salicylaldehyde (Aldrich) reacted with methanesulfonic acid tetrahydro-thiopyran-4-yl ester prepared in Example 130a and potassium carbonate in dimethylformamide to give a solid. MS (H+), 241.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-5d2bbcf707f34790b8e8bf82cddedefc |
| Source note | uspto-grants-2012_03 |