反应详情

After a 100 mL three-neck flask equipped with a magnetic stirrer, a reflux condenser and a thermometer was replaced with Ar, 40.0 mL of methanol, 5 wt % Pd/C (0.40 g) and 7-allyl-5-fluoro-8-quinolinol (4.09 g) were thrown thereto and the mixture was stirred under slight pressurization of hydrogen. After replaced with Ar, the mixture was filtered to remove Pd/C and the filtrate was concentrated to give 3.98 g of 5-fluoro-7-propyl-8-quinolinol as a pale purple solid (yield: 96.0%).

1. customAfter a 100 mL three-neck flask equipped with a magnetic stirrer, a reflux condenser
2. filtrationthe mixture was filtered
3. customto remove Pd/C
4. concentrationthe filtrate was concentrated