HCID 58212270, compound → HCID 58212302, compound

Participants

Reaction Steps

4-[2-Fluoro-4-(4-pentylcylohexyl)-phenyl]-4′-vinyl-bicyclohexyl (No. 5) (1.5 g) obtained in Example 1 was dissolved in a mixed solvent of toluene (15 ml) and Solmix (15 ml), and Pd/C (0.20 g) was added thereto. The mixture was stirred at room temperature under a hydrogen atmosphere until hydrogen absorption had ceased. After the reaction had been completed, Pd/C was removed and then the solvent was distilled off. The residue was purified with a fractional operation by means of column chromatography using heptane as an eluent and silica gel as a stationary phase powder, and further purified by means of recrystallization from heptane and dried, giving 0.78 g of 4-ethyl-4′-(2-fluoro-4-(4-pentylcyclohexyl) phenyl) bi (cyclohexane) (E). The yield based on the compound (No. 5) was 51.8%.

Provenance & Evidence