3-Morpholinecarbonitrile, 5-(4-methoxyphenyl)-5-methyl- → HCID 66781649, compound

HRID 1095318Notes

Reaction equation

HRID 1095318 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH3:17])[NH:14][CH:13]([C:15]#[N:16])[CH2:12][O:11][CH2:10]2)=[CH:5][CH:4]=1>[Ni].C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2([CH3:17])[NH:14][CH:13]([CH2:15][NH2:16])[CH2:12][O:11][CH2:10]2)=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 667820763-Morpholinecarbonitrile, 5-(4-methoxyphenyl)-5-methyl-

Product 1

HCID 66781649HCID 66781649, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 40.1 mmol of 5-(4-methoxyphenyl)-5-methylmorpholine-3-carbonitrile and 2 g of Raney nickel (activated by washing with water to pH 7 and subsequent washing with ethanol) in 200 ml of ethanol is hydrogenated under a pressure of 500 psi for 12 hours. The reaction mixture is filtered through Hyflo and the filtrate is evaporated. The crude title compound is identified from the residue on the basis of the Rf. The title compound is employed without further purification in the next stage.

Workup

  1. filtrationThe reaction mixture is filtered through Hyflo
  2. customthe filtrate is evaporated
  3. customThe title compound is employed without further purification in the next stage

Sources & evidence

ORD record
ord-e411392738e141ea8a75598c429b5e77
Source dataset
uspto-grants-2012_03
Patent number
US08138176B2

Reaction notes

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