Lawesson's reagent → HCID 86632956, compound

HRID 1095321Notes

Reaction equation

HRID 1095321 reaction equation
[NH2:1][C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)([CH3:5])[CH2:3]O.COC1C=CC(P2(=S)SP(=S)(C3C=CC(OC)=CC=3)[S:23]2)=CC=1>C1(C)C=CC=CC=1>[NH2:1][C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][CH:7]=1)([CH3:5])[CH2:3][SH:23]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 61054422HCID 61054422, compound

Product 1

HCID 86632956HCID 86632956, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 1 mmol of 2-amino-2-(4-methoxyphenyl)propan-1-ol (Example 3k) and 0.5 mmol of 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's reagent) [19172-47-5] in 10 ml of toluene is heated to reflux for 2 hours. The reaction mixture is cooled to room temperature and evaporated. The title compound is identified from the residue on the basis of the Rf by flash chromatography (SiO2 60 F).

Workup

  1. temperatureto reflux for 2 hours
  2. customevaporated

Sources & evidence

ORD record
ord-d835e2d9aa0546f0ac4db10d1f7a23bf
Source dataset
uspto-grants-2012_03
Patent number
US08138176B2

Reaction notes

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