反应详情

The product from step (vii) (9.7 g) and (4-formylphenyl)acetic acid (5.4 g) were dissolved in THF (100 ml) and stirred at rt for 4 h. Sodium borohydride (1.9 g) and 5 drops of methanol was added and stirred at a rt overnight. The mixture was quenched with water and concentrated under reduced pressure. Water was added and washed with diethyl ether. 0.1N—HCl was added to acidify the solution to pH 6. The suspension was filtered and the solid collected and dried under reduced pressure to give the subtitle compound. Yield 13 g.

1. stirringstirred at a rt overnight
2. customThe mixture was quenched with water
3. concentrationconcentrated under reduced pressure
4. additionWater was added
5. washwashed with diethyl ether
6. addition0.1N—HCl was added
7. filtrationThe suspension was filtered
8. customthe solid collected
9. customdried under reduced pressure