反应详情

The product from step (ix) (200 mg) was suspended in MeCN. Chloroacetyl chloride (0.02 ml) added and the mixture stirred at rt for 4 h. The mixture was concentrated under reduced pressure, piperazine (0.02 ml) in DMSO (1 ml) was added and the mixture heated at 60° C. for 24 h. The mixture was purified by RPHPLC. Yield 80 mg.

1. concentrationThe mixture was concentrated under reduced pressure, piperazine (0.02 ml) in DMSO (1 ml)
2. additionwas added
3. temperaturethe mixture heated at 60° C. for 24 h
4. customThe mixture was purified by RPHPLC