HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl(4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9h-purin-9-yl)propyl](n,n-dimethylglycyl)amino]methyl}phenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(Dimethylamino)acetyl chloride hydrochloride | HCID 13994991 | — |
| Reactant | Methyl[4-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]amino}methyl)phenyl]acetate | HCID 90697362 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl(4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9h-purin-9-yl)propyl](n,n-dimethylglycyl)amino]methyl}phenyl)acetate | HCID 24961332 | — |
Reaction Steps
The product of example 1, step (ix) (200 mg) was suspended in MeCN. N,N-dimethylglycyl chloride hydrochloride (110 mg) and triethylamine (0.19 ml) were added and the mixture stirred at rt for 10 h. The mixture was purified by RPHPLC. Yield 100 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138172B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-17f49a02c9634a5a8714682b1b9315cb |
| Source note | uspto-grants-2012_03 |