HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (4-{[[3-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-purin-9-yl)-propyl]-(3-piperazin-1-yl-propionyl)-amino]-methyl}-phenyl)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)propanoic acid | HCID 2735644 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Methyl[4-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]amino}methyl)phenyl]acetate | HCID 90697362 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-{[[3-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-purin-9-yl)-propyl]-(3-piperazin-1-yl-propionyl)-amino]-methyl}-phenyl)-acetic acid methyl ester | HCID 24962786 | — |
Reaction Steps
The product of example 1, step (ix) (0.27 g) was dissolved in DCM (10 ml) and treated with 4-(2-carboxy-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (0.16 g) and HATU (0.23 g). The reaction was stirred at rt for 16 h, before 2 mls of TFA added. The mixture was purified by RPHPLC, to give the title compound. Yield 3 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138172B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-05b8fa2dfc674d9fb1ee7aa3510afcc3 |
| Source note | uspto-grants-2012_03 |