Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1095340Generated: October 30, 2026

Ethoxalyl chloride → ethyl (2-ethoxycarbonylmethyl-1H-indol-3-yl)oxoacetate

https://huagongshe.com/reaction/1095340

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthoxalyl chlorideHCID 20884—
ReactantEthyl 2-(1H-indol-2-yl)acetateHCID 11106442—
Productethyl (2-ethoxycarbonylmethyl-1H-indol-3-yl)oxoacetateHCID 57446210—

Reaction Steps

In step (1) of Reaction Scheme VII, ethyl 1H-indol-2-ylacetate is reacted with ethyl chlorooxoacetate to provide ethyl (2-ethoxycarbonylmethyl-1H-indol-3-yl)oxoacetate. The reaction can be carried out using the general method described in step (1) of Reaction Scheme I. Ethyl 1H-indol-2-ylacetate is known.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08138173B2
Source datasetuspto-grants-2012_03
ORD IDord-87d9b8b9194f450aa57795c9a566c33a
Source noteuspto-grants-2012_03