Sodium Carbonate → HCID 57446232, compound

Participants

Reaction Steps

1-[2-(4-Benzylpiperazin-1-yl)ethyl]-4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinoline (0.32 g, 0.66 mmol) was refluxed in 5 mL of 6 N aqueous hydrochloric acid for 1 hour. The mixture was allowed to cool to ambient temperature, and the pH was adjusted to 10 with 10% w/v aqueous sodium carbonate. This mixture was concentrated under reduced pressure, and the residue was purified by automated flash chromatography eluting with a gradient of 0-15% CMA in chloroform. The residue was triturated with acetonitrile, isolated by filtration, and dried to afford 0.050 g of 1-[2-(4-benzylpiperazin-1-yl)ethyl]-2-phenyl-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one as off-white needles, mp 211-212.5° C. MS (ESI) m/z 464 (M+H)+; Anal. calcd for C29H29N5O: C, 75.14; H, 6.31; N, 15.11. Found: C, 74.84; H, 6.35; N, 15.04.

Provenance & Evidence