Thionyl Chloride → HCID 57446241, compound

Participants

Reaction Steps

Thionyl chloride (6.0 mL, 9.9 g, 82.9 mmol) was added dropwise to a stirring suspension of 2-tert-butyl-1-(hydroxymethyl)-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one (4.5 g, 16.6 mmol) in 1,2-dichloroethane (160 mL) and the resulting suspension was stirred at ambient temperature overnight. The volatiles were removed under reduced pressure to yield 5.34 g of 2-tert-butyl-1-(chloromethyl)-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one hydrochloride as a brown solid.

Provenance & Evidence