Hydrochloric Acid → HCID 60209093, compound

Participants

Reaction Steps

A suspension of methyl N-{[3-(2-morpholin-4-ylethyl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]carbonyl}-L-isoleucinate (Example 2) in 4N HCl (4 mL) and acetic acid (4 mL) was refluxed for 24 h. Then it was cooled to rt and evaporated to dryness. Recrystallization from ethyl acetate and hexane followed by filtration gave 510 mg (81%) of the title compound as white solid.

Provenance & Evidence