Water → 3-Methoxy-N2-(2-morpholin-4-ylethyl)benzene-1,2-diamine

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (5.2 g, 136 mmol) in THF (35 mL) was added a solution of N-(2-methoxy-6-nitrophenyl)-2-morpholin-4-ylacetamide (Step 2, 6.7 g, 23 mmol) in THF (40 mL) at 0° C. and stirred at reflux for 2 h. Then to this mixture was added water (5.2 mL) followed by addition of 15% sodium hydroxide (5.2 mL), water (15.6 mL) at 0° C. The mixture was diluted with ethyl acetate (100 mL) and stirred for 3 h at rt. The resultant mixture was filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with dichloromethane/methanol (30/1) to afford 2.5 g (44%) of the title compound.

Provenance & Evidence