Sodium Hydroxide → HCID 25012570, compound

Participants

Reaction Steps

To {2-[3-cyclopentyl methyl-3-(2,5-difluoro-phenyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester (250 mg) in 3 ml THF/MeOH 1:1 was added 3 ml of 1 N NaOH and the reaction stirred 1 h at room temperature then evaporated to dryness in vacuo. Addition of 1 N HCl to pH 1 afforded a precipitate, which was filtered, washed with water and dried to give the title compound (188 mg) as a white solid.

Provenance & Evidence