Sodium Iodide → HCID 57861964, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(3,4-dichlorophenyl)-1H-pyrazol-3-ol (0.2 g, 0.87 mmol; compound prepared in the same way as Example 1, Scheme 1-step 1B), 2-(chloromethyl)oxirane (0.1 g, 1.05 mmol), potassium carbonate (0.36 g, 2.62 mmol) and sodium iodide (0.13 g, 0.87 mmol) in dimethylformamide (6 ml) was warmed, with stirring, to 100° C. for 4 hrs. The solvent was evaporated to dryness in vacuo and residue partitioned between water and dichlorometane. The combined organic phases were dried over sodium sulphate, filtered and evaporated in vacuo to yield 0.24 g of 1-(3,4-dichlorophenyl)-3-(oxiran-2-ylmethoxy)-1H-pyrazole as a dark oil, used without further purification in next step of synthesis.

Provenance & Evidence