Hydrochloric Acid → HCID 66785340, compound

Participants

Reaction Steps

To a magnetically stirred solution of 4-[4-(5-fluoro-1H-indol-3-yl)-4-oxobutyl]-piperazine-1-carboxylic acid tert-butyl ester (3.85 g, 9.88 mmol) in dichloromethane was added hydrochloric acid (dissolved in dioxane: 4.94 ml, 4M solution, 19.8 mmol HCl) and the resulting mixture was reacted at room temperature for 4 hours. The reaction mixture was thoroughly concentrated in vacuo to give 1-(5-fluoro-1H-indol-3-yl)-4-(piperazin-1-yl)butan-1-one dihydrochloride (3.20 g). Some characteristic 1H-NMR signals from 1-(5-fluoro-1H-indol-3-yl)-4-(piperazin-1-yl)butan-1-one dihydrochloride are: (400 MHz, DMSO-d6) δ 2.07 (quintet, J=7, 2H), 3.03 (t, J=7, 2H), 7.08 (dt, J˜9 and 3, 1H), 7.50 (dd, J˜9 and 4, 1H), 7.85 (dd, j˜9 and 3, 1H), 8.43 (d, J˜3, 1H), 12.21 (br s, 1H).

Provenance & Evidence