Ammonia → HCID 59799433, compound

Participants

Reaction Steps

Toluene-4-sulfonic acid 7,7-dimethoxy-7-[4-(trifluoromethyl)phenyl]heptyl ester (1.82 g, 3.835 mmol) was dissolved in a magnetically stirred solution of 7 M NH3 in methanol (30 ml) and stirred at room temperature for 72 hours. After removal of the solvent in vacuo, the residue was dissolved again in dichloromethane and washed with saturated aqueous NaHCO3. The organic layer was subsequently dried over Na2SO4, filtered and concentrated in vacuo to give crude 7,7-dimethoxy-7-[4-(trifluoromethyl)phenyl]heptylamine (1.43 g) which was not further purified. 1H-NMR (400 MHz, CDCl3) δ 0.88-0.95 (m, 2H), 1.12-1.16 (m, 4H), 1.33-1.38 (m, 2H), 1.83-1.88 (m, 2H), 2.59-2.65 (m, 2H), 3.10-3.26 (m, 8H, including —OMe singlet at 3.14), 7.56 (d, J˜8, 2H), 7.60 (d, J˜8, 2H).

Provenance & Evidence