HCID 178494946, compound → HCID 178520602, compound

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Reaction Steps

Part B: 4-Chloro-N-{[3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-[7-(4-fluoro-phenyl)-7,7-dimethoxyheptylamino] methylene}-benzenesulfonamide (0.200 g, 0.258 mmol) was dissolved in a 1:1 mixture of THF/methanol (30 ml) and 1 N hydrochloric acid (5 ml) was added and the resulting mixture was stirred at room temperature for 20 hours. The mixture was quenched with 5% aqueous NaHCO3. Most of the THF and methanol were removed by evaporation in vacuo. The remaining water layer was twice extracted with ethylacetate. The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo. The obtained crude 4-chloro-N-{[3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-[7-(4-fluorophenyl)-7-oxo-heptylamino] methylene}benzenesulfonamide (203 mg) was not further purified. Some characteristic aromatic 1H-NMR signals are: (400 MHz, CDCl3) δ 7.12 (d, J˜8, 2H), 7.22-7.33 (m, 5H) 7.39 (d, J˜8, 2H), 7.50 (d, J˜8, 2H), 7.72 (d, J˜8, 2H), 7.84 (d, J˜8, 2H), 8.05 (d, J˜8, 2H).

Provenance & Evidence