HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-Fluoropyridine-2-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-Bromo-5-fluoropyridine | HCID 2783171 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-Fluoropyridine-2-carboxaldehyde | HCID 10351697 | — |
Reaction Steps
The title compound was prepared according to the methods of preparations 1 and 2, starting from 2-bromo-5-fluoropyridine. This gave crude material containing tetrahydrofuran and diethyl ether which was used without further purification. 1H NMR (CDCl3, 400 MHz) δ 7.57 (1H, dt), 8.03 (1H, dd), 8.62 (1H, d), 10.04 (1H, s); LRMS (APCI+) 126 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138188B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-14f606439f0b4c3999c15bde496aa141 |
| Source note | uspto-grants-2012_03 |