Hydrochloric Acid → HCID 57475101, compound

Participants

Reaction Steps

(8-Benzo[b]thiophen-2-yl-1,4-dioxa-spiro[4.5]dec-8-yl)-dimethyl-amine hydrochloride (0.60 g, 1.7 mmol) was dissolved in water (0.8 ml), concentrated hydrochloric acid (1.04 ml, 151 mmol) was added and the mixture was stirred at room temperature for 3 d. When the hydrolysis had ended, the reaction mixture was extracted with diethyl ether (2×25 ml) and the aqueous phase was rendered alkaline with 5 N sodium hydroxide solution, the mixture was extracted with methylene chloride (3×25 ml) and the extract was dried over sodium sulfate and concentrated i. vac. Yield: 0.44 g (95%) Ket-6

Provenance & Evidence