Hydrochloric Acid → HCID 57475115, compound

Participants

Reaction Steps

First 1,4-dioxaspiro[4,5]decan-8-one (4.84 g, 31 mmol) and thereafter potassium cyanide (4.85 g, 74.4 mmol) in water (15 ml) was added to a mixture of 4N hydrochloric acid (8.1 ml), methanol (4.9 ml) and azetidine (8.5 g, 10 ml, 149 mmol), while cooling with ice. The mixture was stirred at room temperature for 5 d, water (50 ml) was then added and the mixture was extracted with diethyl ether (3×50 ml). The combined organic phases were dried with sodium sulfate and concentrated i. vac.; yield: 6.77 g (98%), oil

Provenance & Evidence