Potassium Hydroxide → HCID 57475123, compound

HRID 1095498Notes

Reaction equation

HRID 1095498 reaction equation
[OH-].[K+].[CH3:3][C:4]1[N:5]=[C:6]([C:9]2([C:19]#[N:20])[CH2:18][CH2:17][C:12]3([O:16][CH2:15][CH2:14][O:13]3)[CH2:11][CH2:10]2)[S:7][CH:8]=1.CC(=O)[O:23]CC.C1CCCCC1>O.C(O)C>[CH3:3][C:4]1[N:5]=[C:6]([C:9]2([C:19]([NH2:20])=[O:23])[CH2:18][CH2:17][C:12]3([O:16][CH2:15][CH2:14][O:13]3)[CH2:11][CH2:10]2)[S:7][CH:8]=1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 21867204Cyclohexane ethylacetateHCID 57475124HCID 57475124, compound

Product 1

HCID 57475123HCID 57475123, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of KOH (12.9 g, 230 mmol) in water (200 ml) was added to 8-(4-methyl-thiazol-2-yl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile (15.2 g, 58 mmol), dissolved in ethanol (200 ml), and the mixture was stirred at RT for 48 h. Since according to TLC (EA/cyclohexane 4:1) educt was still present, the mixture was subsequently stirred at 80° C. for a further 3 h.

Workup

  1. stirringthe mixture was subsequently stirred at 80° C. for a further 3 h.

Sources & evidence

ORD record
ord-3b641b80d1e640dd962d984a3ea04174
Source dataset
uspto-grants-2012_03
Patent number
US08138187B2

Reaction notes

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