1-Methylpiperazine → HCID 15557283, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-Bromo-ethyl)-indole (3.00 g, 13.39 mmol) was initially introduced into abs. CHCl3 (25 ml), and 1-methylpiperazine (2.68 g, 26.8 mmol) was added. The mixture was stirred at a bath temperature of 75° C. for 5 h and at RT overnight. The mixture was extracted dilute sulfuric acid (2×30 ml), the acidic aqueous phase was rendered alkaline with 5N NaOH, while cooling with ice, and the mixture was extracted with ether (3×30 ml). The organic phase was dried over Na2SO4 and concentrated i. vac. Yield: 1.45 g (Ind-68, 45%)

Provenance & Evidence