Thiazolidine → HCID 927517, compound

Participants

Reaction Steps

3-(2-Bromo-ethyl)-indole (3.00 g, 13.4 mmol) and thiazolidine (2.38 g, 26.8 mmol) were stirred in abs. CHCl3 (25 ml) at a bath temperature of 75° C. for 5 h. The mixture was cooled to RT and extracted with dilute sulfuric acid (2×30 ml). The acidic aqueous phase was rendered alkaline with 5N NaOH, while cooling with ice, and extracted with ether (3×30 ml). The organic phase was dried over Na2SO4 and concentrated i. vac. and the residue was purified by flash chromatography with CHCl3/MeOH (20:1→4:1→MeOH).

Provenance & Evidence