Chlorotrimethylsilane → HCID 24953989, compound

Participants

Reaction Steps

1-Butyl-4-(5-fluoro-3-methyl-1H-indol-2-yl)-N,N-dimethylcyclohexanamine (266 mg, 0.8 mmol) was dissolved in ethyl methyl ketone (30 ml). Me3SiCl (20.5 μl, 1.6 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl methyl ketone (2×5 ml) and then dried. Example 79 (193 mg, m.p. 255-265° C., 61%) was a white solid

Provenance & Evidence