Hydrochloric Acid → HCID 24955780, compound

Participants

Reaction Steps

1-Butyl-4-(3-cyclopropyl-1H-indol-2-yl)-N,N-dimethylcyclohexanamine (polar diastereomer) (135 mg, 0.398 mmol) was dissolved in trichloromethane (15 ml) and methanol (10 ml), and a 5 N hydrochloric acid (0.16 ml. 0.8 mmol) in propan-2-ol was added. The lilac-coloured solution was concentrated and diethyl ether (40 ml) was added. After 30 min the hydrochloride was separated off as a lilac-coloured solid by filtration and washing with diethyl ether (2×2 ml). Example 135 was obtained in a yield of 56% (84 mg) with a melting point of 274-276° C.

Provenance & Evidence