Chlorotrimethylsilane → HCID 57475064, compound

Participants

Reaction Steps

4-(2-(4-Benzyl-4-(dimethylamino)cyclohexyl)-1H-indol-3-yl)butanoic acid (260 mg, 0.6 mmol) was dissolved in ethyl acetate (50 ml). Me3SiCl (153 μl, 1.2 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×5 ml) and then dried. Example 171 (197 mg, m.p. 90-93° C., 70%) was obtained as a white solid (purity <95%).

Provenance & Evidence