Chlorotrimethylsilane → HCID 57475068, compound

Participants

Reaction Steps

Acetic acid 4-[2-(4-butyl-4-dimethylaminocyclohexyl)-1H-indol-3-yl]butyl ester (polar diastereomer) (124 mg, 0.3 mmol) was dissolved in ethyl acetate (50 ml). Me3SiCl (76 μl, 0.39 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×5 ml) and then dried. Example 176 (100 mg, m.p. 173-176° C., 74%) was obtained as a white solid.

Provenance & Evidence