Chlorotrimethylsilane → HCID 57475068, compound

Participants

Reaction Steps

Acetic acid 4-[2-(4-butyl-4-dimethylaminocyclohexyl)-1H-indol-3-yl]butyl ester (non-polar diastereomer) (206 mg, 0.5 mmol) was dissolved in ethyl acetate (50 ml). Me3SiCl (126 μl, 1 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×5 ml) and then dried. Example 177 (150 mg, m.p. 128-131° C., 67%) was obtained as a white solid

Provenance & Evidence