Chlorotrimethylsilane → HCID 57475070, compound

Participants

Reaction Steps

4-(2-(4-(Dimethylamino)-4-phenylcyclohexyl)-1H-indol-3-yl)butyl acetate (non-polar diastereomer) (234 mg, 0.54 mmol) was dissolved in ethyl acetate (50 ml). Me3SiCl (136 μl, 1.08 mmol) was then added dropwise at RT. The mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×5 ml) and then dried. Example 178 (155 mg, m.p. 238-241° C., 61%, NMR purity <95%) was obtained as a white solid.

Provenance & Evidence