Chlorotrimethylsilane → HCID 57475070, compound

Participants

Reaction Steps

4-(2-(4-(Dimethylamino)-4-phenylcyclohexyl)-1H-indol-3-yl)butyl acetate (polar diastereomer) (112 mg, 0.26 mmol) was dissolved in ethyl acetate (20 ml). Me3SiCl (65 μl, 0.52 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×5 ml) and then dried. Example 179 (97 mg, m.p. 165-169° C., 80%) was a white solid.

Provenance & Evidence