Chlorotrimethylsilane → HCID 24953997, compound

Participants

Reaction Steps

3-(2-(4-(Dimethylamino)-4-phenylcyclohexyl)-1H-indol-3-yl)propan-1-ol (non-polar diastereomer) (160 mg, 0.43 mmol) was dissolved in ethyl acetate (20 ml). Me3SiCl (108 μl, 0.86 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×5 ml) and then dried. Example 184 (159 mg, m.p. 248-250° C., 90%, NMR purity <95%) was obtained as a white solid.

Provenance & Evidence