Chlorotrimethylsilane → HCID 24953999, compound

Participants

Reaction Steps

3-(2-(4-(Dimethylamino)-4-phenylcyclohexyl)-1H-indol-3-yl)propyl acetate (more polar diastereomer) (60 mg, 0.16 mmol) was dissolved in ethyl acetate (20 ml). Me3SiCl (40 μl, 0.32 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (1×5 ml) and then dried. Example 185 (55 mg, m.p. 229-232° C., 84%) was a white solid.

Provenance & Evidence