反应详情

To a solution of intermediate 1i (74.8 mg, 0.134 mmol) in 3 mL MeOH, was added 80 mg 10% Pd/C. The mixture was evacuated and flushed with H2 (3×), then it was stirred under an atmosphere of H2 for 24 h. The mixture was filtered and concentrated to afford 48 mg (84%) of intermediate 1j. MS (ESI) 427.08 (M+H+).

1. customThe mixture was evacuated
2. customflushed with H2 (3×)
3. filtrationThe mixture was filtered
4. concentrationconcentrated